Monitoring changes in lung air and liquid volumes with electrical impedance tomography

A. Adler 1 , 2 , R. Amyot 3 , R. Guardo 1 , J. H. T. Bates 2 , and Y. Berthiaume 3 3 Centre de Recherche Hôtel-Dieu de Montréal and Department of Medicine, Université de Montréal, 1 Institut de Génie Biomédical, École Polytechnique, and 2 Meakins-Christie Laboratories and Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada H2W 1T8 Received 11 February 1997; accepted in final form 25 June 1997. Adler, A., R. Amyot, R. Guardo, J. H. T. Bates, and Y. Berthiaume. Monitoring changes in lung air and liquid volumes with electrical impedance tomography. J. Appl. Physiol. 83(5): 1762-1767, 1997. Electrical impedance tomography (EIT) uses electrical measurements at electrodes placed around the thorax to image changes in the conductivity distribution within the thorax. This technique is well suited to studying pulmonary function because the movement of air, blood, and extravascular fluid induces significant conductivity changes within the thorax. We conducted three experimental protocols in a total of 19 dogs to assess the accuracy with which EIT can quantify changes in the volumes of both gas and fluid in the lungs. In the first protocol, lung volume increments from 50 to 1,000 ml were applied with a large syringe. EIT measured these volume changes with an average error of 27 ± 6 ml. In the second protocol, EIT measurements were made at end expiration and end inspiration during regular ventilation with tidal volume ranging from 100 to 1,000 ml. The average error in the EIT estimates of tidal volume was 90 ± 43 ml. In the third protocol, lung liquid volume was measured by instilling 5% albumin solution into a lung lobe in increments ranging from 10 to 100 ml. EIT measured these volume changes with an average error of 10 ± 10 ml and was also able to detect into which lobe the fluid had been instilled. These results indicate that EIT can noninvasively measure changes in the volumes of both gas and fluid in the lungs with clinically useful accuracy. lung water; lung volume; thoracic impedance 0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society