RENAL EFFECTS OF ATRIAL NATRIURETIC FACTOR (99-126) IN POTASSIUM LOADED SHEEP

SUMMARY 1. The renal response to renal arterial infusion of synthetic atrial natriuretic factor (ANF 99–126) was examined in conscious sheep following dietary K loading, and compared with the response in normal sheep. 2. Renal arterial infusion of ANF in K loaded sheep increased the excretion of Na...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1989-10, Vol.16 (10), p.807-811
Hauptverfasser:	Yates, N. A., Coghlan, J. P., Scoggins, B. A., McDougall, J. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atrial natriuretic factor Atrial Natriuretic Factor - pharmacology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Infusions, Intra-Arterial Kidney - drug effects Natriuresis - drug effects Peptide Fragments - pharmacology potassium Potassium - pharmacology Potassium - urine potassium excretion potassium loading renal function Sheep sodium excretion Vertebrates: urinary system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	SUMMARY 1. The renal response to renal arterial infusion of synthetic atrial natriuretic factor (ANF 99–126) was examined in conscious sheep following dietary K loading, and compared with the response in normal sheep. 2. Renal arterial infusion of ANF in K loaded sheep increased the excretion of Na and Ca, but did not affect the excretion of K. 3. The natriuretic effect of ANF was attenuated in K loaded animals, possibly as a consequence of the reduction in Na status which is associated with K loading.
ISSN:	0305-1870 1440-1681
DOI:	10.1111/j.1440-1681.1989.tb01519.x