Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth

Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth

A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase c...

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Veröffentlicht in:Connective tissue research 1989, Vol.20 (1-4), p.23-32
Hauptverfasser: Gray, T. K., Lipes, B., Linkhart, T., Mohan, S., Baylink, D.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline Phosphatase - metabolism
Animals
Cell Division - drug effects
Estradiol - pharmacology
Estrogens - pharmacology
Osteoblasts - cytology
Osteoblasts - enzymology
Osteosarcoma - enzymology
Osteosarcoma - pathology
Rats
Transforming Growth Factors - pharmacology
Transforming Growth Factors - physiology
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - enzymology
Tumor Cells, Cultured - pathology
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Zusammenfassung:A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.
ISSN:0300-8207
1607-8438
DOI:10.3109/03008208909023871