Bioactive polymers: LX. Kinetics of delayed release neomycin-xanthan complex

The kinetics of delayed release neomycin-xanthan complex, and its antimicrobial activity, were studied. Delayed release neomycin (53.13% free neomycin) had zero-order release kinetics, when artificial tear solution was used as eluent. Microbiological tests revealed an activity of 380 units/mg, 10% h...

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Veröffentlicht in:	Biomaterials 1989-11, Vol.10 (9), p.622-624
Hauptverfasser:	Beldie, Cameluta, Dumitriu, Severian, Aelenei, Nicolae, Popa, Marcel, Popa, Marcel I., Dumitriu, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics Delayed-Action Preparations Drug delivery In Vitro Techniques Neomycin - pharmacokinetics opthalmic inserts Polysaccharides, Bacterial - pharmacokinetics Prostheses and Implants
Online-Zugang:	Volltext
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Zusammenfassung:	The kinetics of delayed release neomycin-xanthan complex, and its antimicrobial activity, were studied. Delayed release neomycin (53.13% free neomycin) had zero-order release kinetics, when artificial tear solution was used as eluent. Microbiological tests revealed an activity of 380 units/mg, 10% higher than neomycin in its free form.
ISSN:	0142-9612 1878-5905
DOI:	10.1016/0142-9612(89)90117-8