Monitoring minimal residual disease in peripheral blood in B‐lineage acute lymphoblastic leukaemia

The use of peripheral blood rather than marrow has potential advantages for monitoring minimal residual disease during the treatment of leukaemia. To determine the feasibility of using blood, we used a sensitive polymerase chain reaction method to quantify leukaemia in the blood and marrow in 35 pai...

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Veröffentlicht in:	British journal of haematology 1997-11, Vol.99 (2), p.314-319
Hauptverfasser:	Brisco, M. J., Sykes, P. J., Hughes, E., Dolman, G., Neoh, S‐H., Peng, L‐M., Toogood, I., Morley, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukaemia Biological and medical sciences blood Bone Marrow Diseases - pathology Hematologic and hematopoietic diseases Humans Leukemia, B-Cell - blood Leukemia, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences minimal residual neoplasm Neoplasm, Residual - diagnosis peripheral circulation Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology quantification Sensitivity and Specificity
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Zusammenfassung:	The use of peripheral blood rather than marrow has potential advantages for monitoring minimal residual disease during the treatment of leukaemia. To determine the feasibility of using blood, we used a sensitive polymerase chain reaction method to quantify leukaemia in the blood and marrow in 35 paired samples from 15 children during induction treatment. Leukaemic cells in the blood ranged from 1.1 × 10−2 to
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1997.3723186.x