Testicular relapse of acute promyelocytic leukemia after allogeneic BMT

After treatment of acute leukemia (typically ALL and the monocytic variants of AML), relapse may occur at sites other than the marrow. Isolated extramedullary relapse of acute promyelocytic leukemia (APL) however, is rare. We describe such an event in a man who underwent allogeneic BMT for APL in se...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1997-10, Vol.20 (8), p.689-690
Hauptverfasser:	Forrest, D L, Dalal, B I, Naiman, S C, Horsman, D E, Berry, B R, Parslow, M I, Singh, C P, Benny, W B, Barnett, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Acute promyeloid leukemia Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Transplantation Combined Modality Therapy Humans Karyotyping Leukemia Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Leukemia, Promyelocytic, Acute - therapy Male Monocytes Polymerase chain reaction Promyeloid leukemia Stem cell transplantation Testes Testicular Neoplasms - secondary Transcription
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Zusammenfassung:	After treatment of acute leukemia (typically ALL and the monocytic variants of AML), relapse may occur at sites other than the marrow. Isolated extramedullary relapse of acute promyelocytic leukemia (APL) however, is rare. We describe such an event in a man who underwent allogeneic BMT for APL in second relapse and 4 years later presented with testicular relapse. The marrow was morphologically and cytogenetically normal, but RT-PCR analysis revealed the specific PML/RAR chimeric RNA transcript.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1700948