Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin-Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepat...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-11, Vol.278 (5342), p.1464-1466
Hauptverfasser:	HORDIJK, P. L, TEN KLOOSTER, J. P, VAN DER KAMMEN, R. A, MICHIELS, F, OOMEN, L. C. J. M, COLLARD, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Biological and medical sciences Cadherins - metabolism Cell Adhesion Cell Line Cell Line, Transformed Cell Movement Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cytoplasm - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Hepatocyte Growth Factor - pharmacology Intercellular Junctions - metabolism Molecular and cellular biology Neoplasm Invasiveness Phenotype Proteins - genetics Proteins - metabolism rac GTP-Binding Proteins Signal Transduction
Online-Zugang:	Volltext
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