Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the hig...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1989/09/25, Vol.37(9), pp.2531-2532
Hauptverfasser: SHIMIZU, Mineo, HORIE, Syunji, TERASHIMA, Satoshi, UENO, Hajime, HAYASHI, Toshimitsu, ARISAWA, Munehisa, SUZUKI, Shoichi, YOSHIZAKI, Masao, MORITA, Naokata
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Sprache:eng
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Zusammenfassung:Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.37.2531