Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri
Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the hig...
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Veröffentlicht in: | Chemical & pharmaceutical bulletin 1989/09/25, Vol.37(9), pp.2531-2532 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. |
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ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.37.2531 |