General mechanisms of metastasis

In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), a...

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Veröffentlicht in:	Cancer 1997-10, Vol.80 (S8), p.1529-1537
Hauptverfasser:	Woodhouse, Elisa C., Chuaqui, Rodrigo F., Liotta, Lance A.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Biological and medical sciences Bone Neoplasms - secondary cancer Cell Adhesion Cell Adhesion Molecules - physiology chemotaxis Dissemination growth factor Growth Substances - metabolism Humans invasion Medical sciences metastasis Neoplasm Invasiveness Neoplasm Metastasis - pathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology osteolysis osteosclerosis Tissue Inhibitor of Metalloproteinases - physiology Tumor cell Tumors
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Beschreibung
Zusammenfassung:	In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti‐metastasis therapies are being developed. Cancer 1997; 80:1529‐37. © 1997 American Cancer Society.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.0.CO;2-F