Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures

Objectives. This investigation was designed 1) to assess whether the early diastolic velocity of the mitral annulus (Ea) obtained with Doppler tissue imaging (DTI) behaves as a preload-independent index of left ventricular (LV) relaxation; and 2) to evaluate the relation of the mitral E/Earatio to LV filling pressures. Background. Recent observations suggest that Eais an index of LV relaxation that is less influenced by LV filling pressures. Methods. One hundred twenty-five study subjects were classified into three groups according to mitral E/A ratio, LV ejection fraction (LVEF) and clinical symptoms: 34 asymptomatic subjects with a normal LVEF and an E/A ratio ≥1; 40 with a normal LVEF, an E/A ratio 1 (pseudonormal [PN]). Eawas derived from the lateral border of the annulus. A subset of 60 patients had invasive measurement of pulmonary capillary wedge pressure (PCWP) simultaneous with Doppler echocardiographic DTI. Results. Eawas reduced in the IR and PN groups compared with the group of normal subjects: 5.8 ± 1.5 and 5.2 ± 1.4 vs. 12 ± 2.8 cm/s, respectively (p < 0.001). Mean PCWP (20 ± 8 mm Hg) related weakly to mitral E (r = 0.68) but not to Ea. The E/Earatio related well to PCWP (r = 0.87; PCWP = 1.24 [E/Ea] + 1.9), with a difference between Doppler and catheter measurements of 0.1 ± 3.8 mm Hg. Conclusions. Eabehaves as a preload-independent index of LV relaxation. Mitral E velocity, corrected for the influence of relaxation (i.e., the E/Earatio), relates well to mean PCWP and may be used to estimate LV filling pressures.