Aberrant expression of bcl-2 gene family in Down's syndrome brains

Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family...

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Veröffentlicht in:	Brain research. Molecular brain research. 1997-08, Vol.48 (1), p.53-59
Hauptverfasser:	Sawa, Akira, Oyama, Fumitaka, Cairns, Nigel J, Amano, Naoji, Matsushita, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Protein Precursor - biosynthesis Apoptosis Bax Bcl-2 bcl-2-Associated X Protein Bcl-x bcl-X Protein Biological and medical sciences Brain - metabolism Brain - pathology Chromosome aberrations DNA Primers Down Syndrome - genetics Down Syndrome - metabolism Down Syndrome - pathology Down's syndrome Genes, bcl-2 Humans Medical genetics Medical sciences Multigene Family Neurons - metabolism Neurons - pathology Oligonucleotides, Antisense Organ Specificity Polymerase Chain Reaction Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-bcl-2 - biosynthesis Temporal Lobe - metabolism
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Zusammenfassung:	Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/S0169-328X(97)00078-8