Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma
Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. Th...
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| Veröffentlicht in: | European journal of drug metabolism and pharmacokinetics 1997-07, Vol.22 (3), p.207-209 |
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| container_title | European journal of drug metabolism and pharmacokinetics |
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| creator | SCHÜCK, O BOHDANECKA, M SEDIVY, J KRAJICKOVA, M CHADIMOVA, M MATOUSOVIC, K |
| description | Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified. |
| doi_str_mv | 10.1007/BF03189808 |
| format | Article |
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Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.</description><identifier>ISSN: 0378-7966</identifier><identifier>EISSN: 2107-0180</identifier><identifier>DOI: 10.1007/BF03189808</identifier><identifier>PMID: 9358200</identifier><language>eng</language><publisher>Genève: Médecine et hygiène</publisher><subject>Animals ; Biological and medical sciences ; Cyclosporine - blood ; Cyclosporine - pharmacokinetics ; Immunomodulators ; Immunosuppressive Agents - blood ; Immunosuppressive Agents - pharmacokinetics ; Kidney - metabolism ; Male ; Medical sciences ; Nephrectomy - methods ; Pharmacology. 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Drug treatments</subject><subject>Rats</subject><subject>Renal Insufficiency - metabolism</subject><subject>Time Factors</subject><issn>0378-7966</issn><issn>2107-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo67LuxbuQg3gQqpOkaZKjLq4KCx7Uc0nTxK32y6QF9783smWdy2Pm_Rh4D6FzAjcEQNzer4ERqSTIIzSnBEQCRMIxmgMTMhEqy07RMoRPiMOk4jyboZliXFKAOXpdbXX7YQOuWmx2pu5C3_mqtfgOf0UZKhOwdoP12P701leNbQddY2_L0QxV1-LOxaWNp15HNdtdo8_QidN1sMtJF-h9_fC2eko2L4_Pq7tNYqiAIZGOGEYYMFqqUgjHpS2zmISbrISSSM1UoQqd2hRS47ijhqaOKRCkEAVwxxboav-39933aMOQN1Uwtq51a7sx5EIxRRWnEbzeg8Z3IXjr8j4m0X6XE8j_Ssz_S4zwxfR1LBpbHtCpsuhfTr4ORtfO69ZU4YBRmSqZAfsFpUl4ew</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>SCHÜCK, O</creator><creator>BOHDANECKA, M</creator><creator>SEDIVY, J</creator><creator>KRAJICKOVA, M</creator><creator>CHADIMOVA, M</creator><creator>MATOUSOVIC, K</creator><general>Médecine et hygiène</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma</title><author>SCHÜCK, O ; BOHDANECKA, M ; SEDIVY, J ; KRAJICKOVA, M ; CHADIMOVA, M ; MATOUSOVIC, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-8f1c313032d9d77f58ed61895c6d0d18a39b9ba4e404cf5f2c24f39071b7b05f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporine - blood</topic><topic>Cyclosporine - pharmacokinetics</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - blood</topic><topic>Immunosuppressive Agents - pharmacokinetics</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrectomy - methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Renal Insufficiency - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHÜCK, O</creatorcontrib><creatorcontrib>BOHDANECKA, M</creatorcontrib><creatorcontrib>SEDIVY, J</creatorcontrib><creatorcontrib>KRAJICKOVA, M</creatorcontrib><creatorcontrib>CHADIMOVA, M</creatorcontrib><creatorcontrib>MATOUSOVIC, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHÜCK, O</au><au>BOHDANECKA, M</au><au>SEDIVY, J</au><au>KRAJICKOVA, M</au><au>CHADIMOVA, M</au><au>MATOUSOVIC, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma</atitle><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>22</volume><issue>3</issue><spage>207</spage><epage>209</epage><pages>207-209</pages><issn>0378-7966</issn><eissn>2107-0180</eissn><abstract>Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). 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| fulltext | fulltext |
| identifier | ISSN: 0378-7966 |
| ispartof | European journal of drug metabolism and pharmacokinetics, 1997-07, Vol.22 (3), p.207-209 |
| issn | 0378-7966 2107-0180 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79392952 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Cyclosporine - blood Cyclosporine - pharmacokinetics Immunomodulators Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Kidney - metabolism Male Medical sciences Nephrectomy - methods Pharmacology. Drug treatments Rats Renal Insufficiency - metabolism Time Factors |
| title | Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma |
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