Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma

Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. Th...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1997-07, Vol.22 (3), p.207-209
Hauptverfasser:	SCHÜCK, O, BOHDANECKA, M, SEDIVY, J, KRAJICKOVA, M, CHADIMOVA, M, MATOUSOVIC, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclosporine - blood Cyclosporine - pharmacokinetics Immunomodulators Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Kidney - metabolism Male Medical sciences Nephrectomy - methods Pharmacology. Drug treatments Rats Renal Insufficiency - metabolism Time Factors
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Beschreibung
Zusammenfassung:	Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.
ISSN:	0378-7966 2107-0180
DOI:	10.1007/BF03189808