Bioavailability of suckable tablets of oral N-acetylcysteine in man

The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same...

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Veröffentlicht in:	European journal of clinical pharmacology 1989-01, Vol.37 (4), p.419-421
Hauptverfasser:	DE BERNARDI DI VALSERRA, M, MAUTONE, G, BARINDELLI, E, LUALDI, P, FELETTI, F, GALMOZZI, M. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Acetylcysteine - pharmacokinetics Administration, Oral Adult Biological and medical sciences Biological Availability Drug Compounding Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Respiratory system Tablets
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Beschreibung
Zusammenfassung:	The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00558514