New Steroidal Alkaloids from Buxus longifolia

Four new steroidal alkaloids, (+)-cyclovirobuxeine F (1), N-benzoyl-O-acetylbuxalongifoline (2), buxasamarine (3), and (+)-cyclobuxamidine (4), along with two known steroidal bases, 16α-acetoxybuxabenzamidienine (5) and trans-cyclosuffrobuxinine (6), were isolated from the leaves of Buxus longifolia...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-10, Vol.60 (10), p.976-981
Hauptverfasser:	Atta-ur-Rahman, Noor-e-ain, Farhana, Choudhary, M. Iqbal, Parveen, Zeba, Türköz, Songul, Sener, Bilge
Format:	Artikel
Sprache:	eng
Schlagworte:	(+)-CYCLOBUXAMIDINE (+)-CYCLOVIROBUXEINE F 16 ALPHA-ACETOXYBUXABENAMIDIENINE ALCALOIDE ALCALOIDES ALKALOIDS Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology ANTIBACTERIAL PROPERTIES ANTIMICROBIAL PROPERTIES Bacteria - drug effects Biological and medical sciences BUXASAMARINE BUXUS Carbohydrate Sequence CHEMICAL COMPOSITION CHEMICAL STRUCTURE Chromatography, Thin Layer COMPOSICION QUIMICA COMPOSITION CHIMIQUE ESPECTROMETRIA ESTEROIDES ESTRUCTURA QUIMICA FEUILLE General pharmacology HOJAS LEAVES Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Sequence Data N-BENZYOL-O-ACETYLBUXALONGIFOLINE Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STEROIDE STEROIDS STRUCTURE CHIMIQUE TRANS-CYCLOSUFFROBUXININE TURKEY TURQUIA TURQUIE
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Zusammenfassung:	Four new steroidal alkaloids, (+)-cyclovirobuxeine F (1), N-benzoyl-O-acetylbuxalongifoline (2), buxasamarine (3), and (+)-cyclobuxamidine (4), along with two known steroidal bases, 16α-acetoxybuxabenzamidienine (5) and trans-cyclosuffrobuxinine (6), were isolated from the leaves of Buxus longifolia. The alkaloids 1 − 4 showed significant antibacterial activity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970207e