Recurrent mediastinal mass in a child with Hodgkin's disease following successful therapy : a diagnostic challenge

The case of an 11-year-old girl with mediastinal stage III B-E Hodgkin's disease is described. She achieved complete remission with combined chemoradiotherapy according to the Swiss Pediatric Oncology Group-HD Protocol 1985. Six months after all therapy was stopped, a slowly growing retrosterna...

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Veröffentlicht in:	Pediatric surgery international 1997, Vol.12 (8), p.613-617
Hauptverfasser:	FELDGES, A, WAGNER, H. P, BUBECK, B, KEHRER, B, RIES, G, SCHMID, U, WAIBEL, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biopsy, Needle Cancer Child Children & youth Disease Female Follow-Up Studies Hematologic and hematopoietic diseases Hodgkin Disease - diagnosis Hodgkin Disease - drug therapy Hodgkin Disease - radiotherapy Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Mediastinal Neoplasms - diagnosis Mediastinal Neoplasms - drug therapy Mediastinal Neoplasms - radiotherapy Medical sciences Neoplasm Recurrence, Local - diagnosis Radiotherapy, Adjuvant Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed
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Zusammenfassung:	The case of an 11-year-old girl with mediastinal stage III B-E Hodgkin's disease is described. She achieved complete remission with combined chemoradiotherapy according to the Swiss Pediatric Oncology Group-HD Protocol 1985. Six months after all therapy was stopped, a slowly growing retrosternal mass was detected. Computed tomography (CT) and gallium-67 single-photon emission CT (SPECT) could not elucidate the true origin of the tumor, nor did ultrasound-guided transthoracic fine-needle puncture. Open biopsy with histologic examination of the lesion has successfully identified the mass as thymic hyperplasia, a rebound immunologic reaction after chemoradiotherapy that mimicked tumor regrowth.
ISSN:	0179-0358 1437-9813
DOI:	10.1007/BF01371913