Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons

Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the...

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Veröffentlicht in:	Neurochemical research 1997-12, Vol.22 (12), p.1449-1452
Hauptverfasser:	MORIGUCHI, T, MATSUURA, H, KODERA, Y, ITAKURA, Y, KATSUKI, H, SAITO, H, NISHIYAMA, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Cholesterol Cysteine - analogs & derivatives Cysteine - physiology Embryo, Mammalian Fundamental and applied biological sciences. Psychology Garlic Garlic - chemistry Garlic - physiology Hippocampus - cytology Hippocampus - drug effects Isolated neuron and nerve. Neuroglia Nerve Growth Factors - physiology Neurons Neurons - drug effects Plants, Medicinal Rats Rats, Wistar Sulfur - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.
ISSN:	0364-3190 1573-6903
DOI:	10.1023/a:1021946210399