Effect of Gemfibrozil ± Niacin ± Cholestyramine on Endothelial Function in Patients With Serum Low-Density Lipoprotein Cholesterol Levels <160 mg/dl and High-Density Lipoprotein Cholesterol Levels <40 mg/dl

We studied endothelial function using the brachial artery ultrasound model in 100 subjects from the Armed Forces Regression Study, a placebo-controlled, angiographic regression trial in subjects with normal or modestly elevated low-density lipoprotein (LDL) cholesterol and low levels of high-density lipoprotein (HDL) cholesterol treated for 30 months with gemfibrozil and (if necessary) niacin and/or cholestyramine to raise HDL by 25% and lower LDL to