Electrophysiological expression of endothelin and angiotensin receptors in Xenopus oocytes injected with rat heart mRNA

Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca 2+-activated chloride currents in a dose-dependent manner. In addition, n...

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Veröffentlicht in:	FEBS letters 1989-12, Vol.258 (2), p.289-292
Hauptverfasser:	Lory, Philippe, Richard, Sylvain, Rassendren, François A., Tiaho, François, Nargeot, Joël
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin Angiotensin II - pharmacology Angiotensin receptor Animals Biological and medical sciences Ca 2+-activated Cl current Ca2+-activated Cl current Cardiac Ca channels Chloride Channels Chlorides - physiology Electric Conductivity Endothelin receptor Endothelins Endothelium, Vascular - physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Heart Heart Ventricles - drug effects Ion Channels - drug effects Ion Channels - physiology Kinetics Membrane Proteins - physiology Microinjections mRNA mRNA microinjected oocytes Myocardium - metabolism oocytes Oocytes - drug effects Oocytes - metabolism Oocytes - physiology Peptides - pharmacology Rat heart Rats Receptors, Angiotensin - genetics Receptors, Angiotensin - physiology Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Receptors, Endothelin RNA, Messenger - genetics Ventricular Function Vertebrates: cardiovascular system Xenopus
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Zusammenfassung:	Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca 2+-activated chloride currents in a dose-dependent manner. In addition, no direct modulation of expressed or native cardiac Ca channels was observed.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(89)81676-X