Association between Allele 1 of T102C Polymorphism, 5-Hydroxytryptamine 2a Receptor Gene and Schizophrenia in Chinese Males in Singapore
The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an associa...
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| Veröffentlicht in: | Human heredity 1997, Vol.47 (5), p.298-300 |
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| container_title | Human heredity |
| container_volume | 47 |
| creator | Tay, A.H.N. Lim, L.C.C. Lee, W.L. Wong, K.E. Wong, L.Y. Tsoi, W.F. |
| description | The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia. |
| doi_str_mv | 10.1159/000154428 |
| format | Article |
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Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000154428</identifier><identifier>PMID: 9358020</identifier><identifier>CODEN: HUHEAS</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Gene Frequency ; Genes ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Medical sciences ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Receptors, Serotonin - genetics</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Short Communication</subject><subject>Singapore - epidemiology</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v1DAQxS0EKkvhwB0kSyAkJAL-m9jH1artIhWBaDlHjjPpujhxamdFwyfgY-PVLtsLp9G899PM6A1CLyn5SKnUnwghVArB1CO0oILxgpCSPUaLnV7IUrKn6FlKt7lVpOIn6ERzqQgjC_RnmVKwzkwuDLiB6RfAgJfegwdMcejwNSVshb8FP_chjhuX-g9YFuu5jeF-nuI8TqZ3A2Bm8HewME4h4gvIghlafGU37ncYNxEGZ7Ab8GqT2QT4i_GQdsKVG27MGCI8R0864xO8ONRT9OP87Hq1Li6_XnxeLS8LKyo5FRw61alG2JYLpRpbWbCk7TSTQjLNTS6Wllo0jIlSGa4rIYwuDWnAlraR_BS9288dY7jbQprq3iUL3psBwjbVleZKalpl8P0etDGkFKGrx-h6E-eaknqXen1MPbOvD0O3TQ_tkTzEnP23B98ka3wXzWBdOmJMUU0ozdirPfbTxBuIDwv_bXnzX3u9PtsT9dh2D7fcpvyLIyRkfiRVmv8F2kmngA</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Tay, A.H.N.</creator><creator>Lim, L.C.C.</creator><creator>Lee, W.L.</creator><creator>Wong, K.E.</creator><creator>Wong, L.Y.</creator><creator>Tsoi, W.F.</creator><general>S. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Receptors, Serotonin - genetics</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Short Communication</topic><topic>Singapore - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tay, A.H.N.</creatorcontrib><creatorcontrib>Lim, L.C.C.</creatorcontrib><creatorcontrib>Lee, W.L.</creatorcontrib><creatorcontrib>Wong, K.E.</creatorcontrib><creatorcontrib>Wong, L.Y.</creatorcontrib><creatorcontrib>Tsoi, W.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tay, A.H.N.</au><au>Lim, L.C.C.</au><au>Lee, W.L.</au><au>Wong, K.E.</au><au>Wong, L.Y.</au><au>Tsoi, W.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Allele 1 of T102C Polymorphism, 5-Hydroxytryptamine 2a Receptor Gene and Schizophrenia in Chinese Males in Singapore</atitle><jtitle>Human heredity</jtitle><addtitle>Hum Hered</addtitle><date>1997</date><risdate>1997</risdate><volume>47</volume><issue>5</issue><spage>298</spage><epage>300</epage><pages>298-300</pages><issn>0001-5652</issn><eissn>1423-0062</eissn><coden>HUHEAS</coden><abstract>The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger</pub><pmid>9358020</pmid><doi>10.1159/000154428</doi><tpages>3</tpages></addata></record> |
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| ispartof | Human heredity, 1997, Vol.47 (5), p.298-300 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adult and adolescent clinical studies Alleles Asian Continental Ancestry Group - genetics Biological and medical sciences Gene Frequency Genes Genotype Humans Linkage Disequilibrium Male Medical sciences Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, Serotonin - genetics Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Short Communication Singapore - epidemiology |
| title | Association between Allele 1 of T102C Polymorphism, 5-Hydroxytryptamine 2a Receptor Gene and Schizophrenia in Chinese Males in Singapore |
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