Association between Allele 1 of T102C Polymorphism, 5-Hydroxytryptamine 2a Receptor Gene and Schizophrenia in Chinese Males in Singapore

Association between Allele 1 of T102C Polymorphism, 5-Hydroxytryptamine 2a Receptor Gene and Schizophrenia in Chinese Males in Singapore

The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an associa...

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Veröffentlicht in:Human heredity 1997, Vol.47 (5), p.298-300
Hauptverfasser: Tay, A.H.N., Lim, L.C.C., Lee, W.L., Wong, K.E., Wong, L.Y., Tsoi, W.F.
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
Alleles
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Gene Frequency
Genes
Genotype
Humans
Linkage Disequilibrium
Male
Medical sciences
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptors, Serotonin - genetics
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Short Communication
Singapore - epidemiology
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Zusammenfassung:The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia.
ISSN:0001-5652
1423-0062
DOI:10.1159/000154428