Positioning of 72 potentially full size LTRs of human endogenous retroviruses HERV-K on the human chromosome 19 map. Occurrences of the LTRs in human gene sites

Seventy-two near full size long terminal repeats (LTRs) of human endogenous retrovirus of K-family (HERV-K) have been precisely located on the metric map of human chromosome 19. The LTR-related sequences were identified and assigned to cosmids by hybridization with two independent chromosome 19 spec...

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Veröffentlicht in:	Gene 1997-10, Vol.199 (1), p.255-264
Hauptverfasser:	Vinogradova, T, Volik, S, Lebedev, Yu, Shevchenko, Yu, Lavrentyeva, I, Khil, P, Grzeschik, K.-H, Ashworth, L.K, Sverdlov, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chromosome Mapping Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 19 - virology Cosmids - genetics Gene expression regulation Genes - genetics Humans Molecular genetics Molecular Sequence Data Physical mapping Repetitive Sequences, Nucleic Acid - genetics Retroviridae - genetics Sequence Homology, Nucleic Acid
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Zusammenfassung:	Seventy-two near full size long terminal repeats (LTRs) of human endogenous retrovirus of K-family (HERV-K) have been precisely located on the metric map of human chromosome 19. The LTR-related sequences were identified and assigned to cosmids by hybridization with two independent chromosome 19 specific cDNA clones corresponding to different parts of U3 region of LTR of HERV-K. The presence of full-size LTR sequences in a cosmid was further verified by PCR assay with a pair of primers complementary to the termini of the LTR. Coincidences of the LTR and the known genes positions are discussed.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/S0378-1119(97)00376-4