Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA

The adenovirus proteinase (AVP) uses both an 11-amino acid peptide (pVlc) 1,2 and the viral DNA 1 as cofactors to increase its catalytic rate constant 6000-fold. The crystal structure 3 of an AVP-pVlc complex at 2.6-Å resolution reveals a new protein fold of an enzyme that is the first member of a n...

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Veröffentlicht in:	Trends in Biochemical Sciences 1997-10, Vol.22 (10), p.393-398
Hauptverfasser:	Mangel, Walter F., Toledo, Diana L., Ding, Jianzhong, Sweet, Robert M., McGrath, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - enzymology Cysteine Endopeptidases - metabolism DNA, Viral - physiology Models, Molecular Protein Structure, Secondary Time Factors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The adenovirus proteinase (AVP) uses both an 11-amino acid peptide (pVlc) 1,2 and the viral DNA 1 as cofactors to increase its catalytic rate constant 6000-fold. The crystal structure 3 of an AVP-pVlc complex at 2.6-Å resolution reveals a new protein fold of an enzyme that is the first member of a new class of cysteine proteinases, which arose via convergent evolution.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(97)01123-7