Role and regulation of phospholipase D activity in normal and cancer cells

PLD is regulated by the small GTP binding proteins Rho and Arf, though predominantly by the latter. The PA product of PLD activation is an activator of Rho-regulated actin stress fibre formation and in invasive cells of MMP-9 synthesis and activation. Together this may explain the increased invasion...

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Veröffentlicht in:	Advances in enzyme regulation 1997, Vol.37, p.29-34
Hauptverfasser:	Wakelam, Michael J.O., Martin, Ashley, Hodgkin, Matthew N., Brown, Fraser, Pettitt, Trevor R., Cross, Michael J., De Takats, Philippa G., Reynolds, Joanne L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism ADP-Ribosylation Factors Blotting, Western Cell Membrane - enzymology Cell Movement - physiology Edetic Acid - pharmacology Enzyme Activation GTP-Binding Proteins - metabolism GTP-Binding Proteins - pharmacology Guanosine 5'-O-(3-Thiotriphosphate) - metabolism HL-60 Cells Humans Lipids - analysis Metalloendopeptidases - metabolism Phosphatidic Acids - metabolism Phosphatidic Acids - pharmacology Phospholipase D - metabolism rhoA GTP-Binding Protein
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Beschreibung
Zusammenfassung:	PLD is regulated by the small GTP binding proteins Rho and Arf, though predominantly by the latter. The PA product of PLD activation is an activator of Rho-regulated actin stress fibre formation and in invasive cells of MMP-9 synthesis and activation. Together this may explain the increased invasion of cells in response to PA.
ISSN:	0065-2571 1873-2437
DOI:	10.1016/S0065-2571(96)00023-4