Discovering High-Affinity Ligands for Proteins
Researchers have developed a method for producing high-affinity ligands in which small molecules that bind to proximal subsites of a protein are identified in an NMR-based screen and then linked together in their experimentally determined bound orientations.
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5337), p.497-499 |
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| container_end_page | 499 |
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| container_issue | 5337 |
| container_start_page | 497 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 278 |
| creator | Hajduk, Philip J. Meadows, Robert P. Fesik, Stephen W. |
| description | Researchers have developed a method for producing high-affinity ligands in which small molecules that bind to proximal subsites of a protein are identified in an NMR-based screen and then linked together in their experimentally determined bound orientations. |
| doi_str_mv | 10.1126/science.278.5337.497 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5337), p.497-499 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79377395 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Amides Chemistry Chemistry, Pharmaceutical - methods Computer Simulation Drug Design Drugs Electronic Libraries Enzymes Libraries Ligands Magnetic Resonance Spectroscopy Models, Molecular Molecular structure Molecules Nuclear magnetic resonance Organic Chemistry Product development Proteins Proteins - metabolism Small libraries Solubility Structure-Activity Relationship Tech.Sight Water |
| title | Discovering High-Affinity Ligands for Proteins |
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