Discovering High-Affinity Ligands for Proteins

Discovering High-Affinity Ligands for Proteins

Researchers have developed a method for producing high-affinity ligands in which small molecules that bind to proximal subsites of a protein are identified in an NMR-based screen and then linked together in their experimentally determined bound orientations.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5337), p.497-499
Hauptverfasser: Hajduk, Philip J., Meadows, Robert P., Fesik, Stephen W.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Chemistry
Chemistry, Pharmaceutical - methods
Computer Simulation
Drug Design
Drugs
Electronic Libraries
Enzymes
Libraries
Ligands
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular structure
Molecules
Nuclear magnetic resonance
Organic Chemistry
Product development
Proteins
Proteins - metabolism
Small libraries
Solubility
Structure-Activity Relationship
Tech.Sight
Water
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Beschreibung
Zusammenfassung:Researchers have developed a method for producing high-affinity ligands in which small molecules that bind to proximal subsites of a protein are identified in an NMR-based screen and then linked together in their experimentally determined bound orientations.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.278.5337.497