Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury

We evaluated the efficacy of insulin-like growth factor-1 (IGF-1) in attenuating neurobehavioral deficits following lateral fluid percussion (FP) brain injury. Male Sprague–Dawley rats (345–425 g,n=88) were anesthetized and subjected to FP brain injury of moderate severity (2.4–2.9 atm). In Study 1,...

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Veröffentlicht in:	Experimental neurology 1997-10, Vol.147 (2), p.418-427
Hauptverfasser:	Saatman, Kathryn E., Contreras, Patricia C., Smith, Douglas H., Raghupathi, Ramesh, McDermott, Kelli L., Fernandez, Seamus C., Sanderson, Kristin L., Voddi, Madhu, McIntosh, Tracy K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Damage, Chronic - etiology Brain Damage, Chronic - prevention & control Brain Injuries - complications Brain Injuries - drug therapy Cognition Disorders - etiology Cognition Disorders - prevention & control Infusion Pumps, Implantable Insulin-Like Growth Factor I - administration & dosage Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor I - therapeutic use Learning Disorders - etiology Learning Disorders - prevention & control Male Maze Learning - drug effects Medical sciences Miscellaneous Movement Disorders - etiology Movement Disorders - prevention & control Neuropharmacology Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Pharmacology. Drug treatments Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Reaction Time - drug effects Time Factors Wounds, Nonpenetrating - drug therapy
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Zusammenfassung:	We evaluated the efficacy of insulin-like growth factor-1 (IGF-1) in attenuating neurobehavioral deficits following lateral fluid percussion (FP) brain injury. Male Sprague–Dawley rats (345–425 g,n=88) were anesthetized and subjected to FP brain injury of moderate severity (2.4–2.9 atm). In Study 1, IGF-1 (1.0 mg/kg,n=9) or vehicle (n=14) was administered by subcutaneous injection at 15 min postinjury and similarly at 12-h intervals for 14 days. In animals evaluated daily for 14 days, IGF-1 treatment attenuated motor dysfunction over the 2-week period (P
ISSN:	0014-4886 1090-2430
DOI:	10.1006/exnr.1997.6629