Glucose-Stimulated Insulin Secretion from Rat Islets of Langerhans Is Independent of Mitogen-Activated Protein Kinase Activation

Glucose-Stimulated Insulin Secretion from Rat Islets of Langerhans Is Independent of Mitogen-Activated Protein Kinase Activation

The role played by mitogen-activated protein kinases (MAPKs) in the regulation of insulin secretion from adult rat islets of Langerhans was investigated by examining the effects of glucose, forskolin and 4β phorbol myristate acetate (PMA) on islet MAPK activity and by measuring insulin secretion fro...

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Veröffentlicht in:Biochemical and biophysical research communications 1997-10, Vol.239 (2), p.447-450
Hauptverfasser: Burns, C.J., Howell, S.L., Jones, P.M., Persaud, S.J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Enzyme Activation
Enzyme Inhibitors - pharmacology
Flavonoids - pharmacology
Glucose - pharmacology
Immunoblotting
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - drug effects
Islets of Langerhans - enzymology
Islets of Langerhans - metabolism
Male
Peptides - metabolism
Rats
Rats, Sprague-Dawley
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Zusammenfassung:The role played by mitogen-activated protein kinases (MAPKs) in the regulation of insulin secretion from adult rat islets of Langerhans was investigated by examining the effects of glucose, forskolin and 4β phorbol myristate acetate (PMA) on islet MAPK activity and by measuring insulin secretion from islets in response to these agonists after inhibition of MAPK by PD 098059 (PD). Glucose (20mM) had a small (
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1997.7486