The cardiovascular safety of triphasic contraceptive steroids

It was hypothesized that estrogen-induced cardioprotection is mediated by up-regulation and down-regulation of expression of nitric oxide (NO) and P-selectin, respectively. Published data on circulating levels of the vasodilator NO, atherogenic glycoprotein P-selectin, and lipoprotein-a [Lp(a)] in u...

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Veröffentlicht in:	Contraception (Stoneham) 1997-09, Vol.56 (3), p.157-163
Hauptverfasser:	Shaarawy, Mohamed, Nafea, Sami, Abdel-Aziz, Omar, Rahseed, Khalid, Sheiba, Mamdouh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Birth control Cardiovascular Diseases - blood Cardiovascular Diseases - prevention & control cardiovascular safety Contraceptives, Oral - pharmacology Estradiol Congeners - administration & dosage Estradiol Congeners - pharmacology Ethinyl Estradiol - administration & dosage Ethinyl Estradiol - pharmacology Female Gynecology. Andrology. Obstetrics Hormonal contraception Humans Levonorgestrel - administration & dosage Levonorgestrel - pharmacology lipoprotein (a) Lipoprotein(a) - blood Medical sciences nitric oxide Nitric Oxide - blood P-selectin P-Selectin - blood Population Progesterone Congeners - administration & dosage Progesterone Congeners - pharmacology triphasic contraceptive steroids
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Zusammenfassung:	It was hypothesized that estrogen-induced cardioprotection is mediated by up-regulation and down-regulation of expression of nitric oxide (NO) and P-selectin, respectively. Published data on circulating levels of the vasodilator NO, atherogenic glycoprotein P-selectin, and lipoprotein-a [Lp(a)] in users of triphasic contraceptive steroids are lacking. A total of 30 healthy women (nonusers, controls) and 82 women using oral triphasic contraceptive steroids (ethinyl estradiol and levonorgestrel: Triovlar, Schering AG) for 18 to 24 cycles participated in this study. Fasting blood samples were obtained from users and nonusers for the determination of P-selectin and Lp(a) by enzyme immunoassay and NO by a colorimetric method. The serum Lp(a) levels in OC users were significantly higher than those of nonusers. On the other hand, the serum NO levels in OC users were significantly elevated when compared to nonusers. Plasma P-selectin was significantly lowered in OC users p
ISSN:	0010-7824 1879-0518
DOI:	10.1016/S0010-7824(97)00114-5