Is postburn dermal ischaemia enhanced by oxygen free radicals?

The accumulated data suggest that oxygen free radicals are actively involved in the pathophysiology of the wound healing process. Since OH and O 2 — directly correlate with the release of arachidonic acid and catalyse some of the enzymes participating in its cascade, their involvement in the enhance...

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Veröffentlicht in:	Burns 1989-10, Vol.15 (5), p.291-294
Hauptverfasser:	Kaufman, T., Neuman, R.A., Weinberg, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Burns Burns - physiopathology Free Radicals Humans Hydrogen Peroxide - metabolism Hydroxides - metabolism Hydroxyl Radical Ischemia - physiopathology Lipid Peroxides - metabolism Medical sciences Oxygen Consumption Skin - blood supply Traumas. Diseases due to physical agents Wound Healing - physiology
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Zusammenfassung:	The accumulated data suggest that oxygen free radicals are actively involved in the pathophysiology of the wound healing process. Since OH and O 2 — directly correlate with the release of arachidonic acid and catalyse some of the enzymes participating in its cascade, their involvement in the enhancement of dermal ischaemia in the stasis zone is postulated. Experimental data using topically applied scavengers of superoxide have shown their beneficial effects on the burn wound healing process.
ISSN:	0305-4179 1879-1409
DOI:	10.1016/0305-4179(89)90004-1