Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin

Follistatin, a hormone which acts to suppress the release of follicle-stimulating hormone (FSH) by pituitary-derived gonadotrophs, has previously been identified only in the liquor folliculi of ovarian follicles. By microsequencing of fractions derived from conditioned medium, we show here that bovi...

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Veröffentlicht in:Biochemical and biophysical research communications 1989-11, Vol.165 (1), p.292-298
Hauptverfasser: Gospodarowicz, D., Lau, K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Follistatin, a hormone which acts to suppress the release of follicle-stimulating hormone (FSH) by pituitary-derived gonadotrophs, has previously been identified only in the liquor folliculi of ovarian follicles. By microsequencing of fractions derived from conditioned medium, we show here that bovine pituitary-derived folliculo stellate cells are also capable of producing and secreting this hormone. These results suggest that folliculo stellate cells may serve as a source of follistatin within the pituitary itself and that the regulation of FSH release from the pituitary could therefore involve a paracrine mechanism.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(89)91068-1