18-Substituted steroids. Part 15. 6 beta-Hydroxylation of aldosterone by liver
6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enz...
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| Veröffentlicht in: | Steroids 1989-08, Vol.54 (2), p.169-184 |
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| container_title | Steroids |
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| creator | Kirk, D N Burke, P J Toms, H C Latif, S A Morris, D J |
| description | 6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. Periodate degradation of the 6 beta-hydroxyaldosterone gave 6 beta-hydroxyaldosterone gamma-lactone, identical with a synthetic sample. |
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Part 15. 6 beta-Hydroxylation of aldosterone by liver</title><title>Steroids</title><addtitle>Steroids</addtitle><description>6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. 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| ispartof | Steroids, 1989-08, Vol.54 (2), p.169-184 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Aldosterone - analogs & derivatives Aldosterone - chemical synthesis Aldosterone - metabolism Animals Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Hydroxylation Hydroxyprogesterones - analysis In Vitro Techniques Liver - metabolism Magnetic Resonance Spectroscopy Male Rats Rats, Inbred Strains Spectrophotometry, Ultraviolet |
| title | 18-Substituted steroids. Part 15. 6 beta-Hydroxylation of aldosterone by liver |
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