18-Substituted steroids. Part 15. 6 beta-Hydroxylation of aldosterone by liver

6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enz...

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Veröffentlicht in:	Steroids 1989-08, Vol.54 (2), p.169-184
Hauptverfasser:	Kirk, D N, Burke, P J, Toms, H C, Latif, S A, Morris, D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - analogs & derivatives Aldosterone - chemical synthesis Aldosterone - metabolism Animals Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Hydroxylation Hydroxyprogesterones - analysis In Vitro Techniques Liver - metabolism Magnetic Resonance Spectroscopy Male Rats Rats, Inbred Strains Spectrophotometry, Ultraviolet
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Zusammenfassung:	6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. Periodate degradation of the 6 beta-hydroxyaldosterone gave 6 beta-hydroxyaldosterone gamma-lactone, identical with a synthetic sample.
ISSN:	0039-128X