Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells
A VARIETY of neurologic disorders are associated with different forms of cancer. 1 2 3 4 5 6 7 Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight. 8 9 10 11 There have been several...
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| Veröffentlicht in: | The New England journal of medicine 1989-12, Vol.321 (23), p.1589-1594 |
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| container_issue | 23 |
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| container_title | The New England journal of medicine |
| container_volume | 321 |
| creator | Thirkill, Charles E FitzGerald, Paul Sergott, Robert C Roth, Alan M Tyler, Nancy K Keltner, John L |
| description | A VARIETY of neurologic disorders are associated with different forms of cancer.
1
2
3
4
5
6
7
Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight.
8
9
10
11
There have been several published reports of central nervous system autoantibodies in patients with cancer, primarily small-cell carcinoma of the lung with associated neuropathies.
12
13
14
15
16
17
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19
20
21
22
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24
25
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We previously described
30
high titers of serum antibodies reactive with retinal components in patients with cancer who experienced a sudden, unexplained reduction in vision before the cancer was diagnosed. This study involved a patient with symptoms of cancer-associated retinopathy (the . . . |
| doi_str_mv | 10.1056/NEJM198912073212307 |
| format | Article |
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1
2
3
4
5
6
7
Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight.
8
9
10
11
There have been several published reports of central nervous system autoantibodies in patients with cancer, primarily small-cell carcinoma of the lung with associated neuropathies.
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
We previously described
30
high titers of serum antibodies reactive with retinal components in patients with cancer who experienced a sudden, unexplained reduction in vision before the cancer was diagnosed. This study involved a patient with symptoms of cancer-associated retinopathy (the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198912073212307</identifier><identifier>PMID: 2555714</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Animals ; Antigens ; Antigens, Neoplasm - immunology ; Autoantibodies - analysis ; Autoimmune Diseases - etiology ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Biopsy ; Blotting, Western ; Cancer ; Carcinoma, Small Cell - complications ; Carcinoma, Small Cell - immunology ; Colleges & universities ; Female ; Guinea Pigs ; Humans ; Immunization, Passive ; Immunoglobulins ; Immunohistochemistry ; Lung Neoplasms - complications ; Lung Neoplasms - immunology ; Medical sciences ; Middle Aged ; Optic nerve ; Optic Nerve - immunology ; Paraneoplastic Syndromes - immunology ; Pneumology ; Retina - immunology ; Retinal Diseases - etiology ; Retinal Diseases - immunology ; Tumors of the respiratory system and mediastinum</subject><ispartof>The New England journal of medicine, 1989-12, Vol.321 (23), p.1589-1594</ispartof><rights>1990 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Dec 7, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-8c45105b104b4f90f2fe065fb89893b55609ecfc371f4d7aac8107330718d5e83</citedby><cites>FETCH-LOGICAL-c393t-8c45105b104b4f90f2fe065fb89893b55609ecfc371f4d7aac8107330718d5e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1882589686?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,64374,64376,64378,72230</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6900381$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2555714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thirkill, Charles E</creatorcontrib><creatorcontrib>FitzGerald, Paul</creatorcontrib><creatorcontrib>Sergott, Robert C</creatorcontrib><creatorcontrib>Roth, Alan M</creatorcontrib><creatorcontrib>Tyler, Nancy K</creatorcontrib><creatorcontrib>Keltner, John L</creatorcontrib><title>Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>A VARIETY of neurologic disorders are associated with different forms of cancer.
1
2
3
4
5
6
7
Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight.
8
9
10
11
There have been several published reports of central nervous system autoantibodies in patients with cancer, primarily small-cell carcinoma of the lung with associated neuropathies.
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
We previously described
30
high titers of serum antibodies reactive with retinal components in patients with cancer who experienced a sudden, unexplained reduction in vision before the cancer was diagnosed. This study involved a patient with symptoms of cancer-associated retinopathy (the . . .</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Autoantibodies - analysis</subject><subject>Autoimmune Diseases - etiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blotting, Western</subject><subject>Cancer</subject><subject>Carcinoma, Small Cell - complications</subject><subject>Carcinoma, Small Cell - immunology</subject><subject>Colleges & universities</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - immunology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Optic nerve</subject><subject>Optic Nerve - immunology</subject><subject>Paraneoplastic Syndromes - immunology</subject><subject>Pneumology</subject><subject>Retina - immunology</subject><subject>Retinal Diseases - etiology</subject><subject>Retinal Diseases - immunology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kVtLJDEQhcOi6Kj7C0QIKKKsvSadpDt5HBpdV7yAl-cmna5ohr6MSY8y_97s9uCDiHnJQ32nqs4phHYp-U2JyE5vzi6vqZKKpiRnKU0ZyX-gCRWMJZyTbA1NCEllwnPFNtFWCDMSH-VqA22kQoic8gl6KXRnwCfTEHrj9AA1voPBdf1cD89LfFRM7_D9sqt938IxfnPDM552g6v62kGIqDYRfhoL_4W6OcG388GZ5Ab8K5xg3dV4HIILaJqwg9atbgL8XP3b6PH87KG4SK5u__wtpleJYYoNiTRcRJcVJbziVhGbWiCZsJWMjlklREYUGGtYTi2vc62NpDGGmAGVtQDJttHh2Hfu-5cFhKFsXTBxA91BvwhlTIUrQfMI7n8CZ_3CRyOhpFKmQqpMZpFiI2V8H4IHW869a7VflpSU_85RfnGOqNpb9V5ULdQfmlX-sX6wqutgdGN9DMqFDyxThDBJI_ZrxNo2lB3M2m-HvgP3I5w2</recordid><startdate>19891207</startdate><enddate>19891207</enddate><creator>Thirkill, Charles E</creator><creator>FitzGerald, Paul</creator><creator>Sergott, Robert C</creator><creator>Roth, Alan M</creator><creator>Tyler, Nancy K</creator><creator>Keltner, John L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19891207</creationdate><title>Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells</title><author>Thirkill, Charles E ; FitzGerald, Paul ; Sergott, Robert C ; Roth, Alan M ; Tyler, Nancy K ; Keltner, John L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-8c45105b104b4f90f2fe065fb89893b55609ecfc371f4d7aac8107330718d5e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Autoantibodies - analysis</topic><topic>Autoimmune Diseases - etiology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blotting, Western</topic><topic>Cancer</topic><topic>Carcinoma, Small Cell - complications</topic><topic>Carcinoma, Small Cell - immunology</topic><topic>Colleges & universities</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunoglobulins</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - immunology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Optic nerve</topic><topic>Optic Nerve - immunology</topic><topic>Paraneoplastic Syndromes - immunology</topic><topic>Pneumology</topic><topic>Retina - immunology</topic><topic>Retinal Diseases - etiology</topic><topic>Retinal Diseases - immunology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thirkill, Charles E</creatorcontrib><creatorcontrib>FitzGerald, Paul</creatorcontrib><creatorcontrib>Sergott, Robert C</creatorcontrib><creatorcontrib>Roth, Alan M</creatorcontrib><creatorcontrib>Tyler, Nancy K</creatorcontrib><creatorcontrib>Keltner, John L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thirkill, Charles E</au><au>FitzGerald, Paul</au><au>Sergott, Robert C</au><au>Roth, Alan M</au><au>Tyler, Nancy K</au><au>Keltner, John L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1989-12-07</date><risdate>1989</risdate><volume>321</volume><issue>23</issue><spage>1589</spage><epage>1594</epage><pages>1589-1594</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>A VARIETY of neurologic disorders are associated with different forms of cancer.
1
2
3
4
5
6
7
Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight.
8
9
10
11
There have been several published reports of central nervous system autoantibodies in patients with cancer, primarily small-cell carcinoma of the lung with associated neuropathies.
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
We previously described
30
high titers of serum antibodies reactive with retinal components in patients with cancer who experienced a sudden, unexplained reduction in vision before the cancer was diagnosed. This study involved a patient with symptoms of cancer-associated retinopathy (the . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>2555714</pmid><doi>10.1056/NEJM198912073212307</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1989-12, Vol.321 (23), p.1589-1594 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| subjects | Animals Antigens Antigens, Neoplasm - immunology Autoantibodies - analysis Autoimmune Diseases - etiology Autoimmune Diseases - immunology Biological and medical sciences Biopsy Blotting, Western Cancer Carcinoma, Small Cell - complications Carcinoma, Small Cell - immunology Colleges & universities Female Guinea Pigs Humans Immunization, Passive Immunoglobulins Immunohistochemistry Lung Neoplasms - complications Lung Neoplasms - immunology Medical sciences Middle Aged Optic nerve Optic Nerve - immunology Paraneoplastic Syndromes - immunology Pneumology Retina - immunology Retinal Diseases - etiology Retinal Diseases - immunology Tumors of the respiratory system and mediastinum |
| title | Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells |
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