Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells
A VARIETY of neurologic disorders are associated with different forms of cancer. 1 2 3 4 5 6 7 Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight. 8 9 10 11 There have been several...
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| Veröffentlicht in: | The New England journal of medicine 1989-12, Vol.321 (23), p.1589-1594 |
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| Format: | Artikel |
| Sprache: | eng |
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| Zusammenfassung: | A VARIETY of neurologic disorders are associated with different forms of cancer.
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Secondary neurologic effects that become manifest in the absence of metastasis are collectively called paraneoplastic phenomena, and they include the rapid loss of sight.
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There have been several published reports of central nervous system autoantibodies in patients with cancer, primarily small-cell carcinoma of the lung with associated neuropathies.
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We previously described
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high titers of serum antibodies reactive with retinal components in patients with cancer who experienced a sudden, unexplained reduction in vision before the cancer was diagnosed. This study involved a patient with symptoms of cancer-associated retinopathy (the . . . |
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| ISSN: | 0028-4793 1533-4406 |
| DOI: | 10.1056/NEJM198912073212307 |