Differential distribution of GABAA receptor mRNAs in bovine cerebellum--localization of alpha 2 mRNA in Bergmann glia layer

Differential distribution of GABAA receptor mRNAs in bovine cerebellum--localization of alpha 2 mRNA in Bergmann glia layer

Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells,...

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Veröffentlicht in:Neuroscience letters 1989-11, Vol.106 (1-2), p.7-12
Hauptverfasser: Wisden, W, McNaughton, L A, Darlison, M G, Hunt, S P, Barnard, E A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cattle
Cerebellum - cytology
Cerebellum - metabolism
Nucleic Acid Hybridization
Receptors, GABA-A - metabolism
RNA, Messenger - metabolism
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Zusammenfassung:Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the alpha 2 mRNA appears to be confined to the Bergmann glial cell layer. The alpha 3 mRNA is only expressed in the Golgi cells. This differential distribution of GABAA receptor mRNA subtypes suggests a previously unrecognized complexity of GABAergic transmission in the cerebellum.
ISSN:0304-3940