Relation between lipoprotein(a) concentrations in patients with acute-phase response and risk analysis for coronary heart disease

This study investigated whether lipoprotein(a) [Lp(a)] is an acute-phase reactant that can cause important bias in risk factor analysis for coronary heart disease among patients with an acute-phase response (APR patients). To determine whether serum Lp(a) concentrations increase among APR patients,...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 1997-10, Vol.43 (10), p.1891-1895
Hauptverfasser:	Min, Won-Ki, Lee, Jae Ok, Huh, Jung Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - blood Adult Apolipoproteins A - genetics Biological and medical sciences Cardiovascular system Coronary Disease - blood Female Humans Investigative techniques, diagnostic techniques (general aspects) Lipoprotein(a) - blood Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype
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Zusammenfassung:	This study investigated whether lipoprotein(a) [Lp(a)] is an acute-phase reactant that can cause important bias in risk factor analysis for coronary heart disease among patients with an acute-phase response (APR patients). To determine whether serum Lp(a) concentrations increase among APR patients, we compared the Lp(a) concentrations and apolipoprotein(a) [apo(a)] phenotypes of 100 controls with those of a random sampling of 100 APR patients. Serum Lp(a) concentration was measured by ELISA; Lp(a) phenotyping was performed by electrophoresis on sodium dodecyl sulfate-polyacrylamide gel. Lp(a) was significantly (P
ISSN:	0009-9147 1530-8561
DOI:	10.1093/clinchem/43.10.1891