Identification of fatty acid amides in human plasma

A family of five long-chain fatty acid carboxamides has been identified and semi-quantified in human plasma by GC-MS. One saturated and four unsaturated amides were found. Luteal phase plasma from 16 women was studied, and all five of the amides were found in ten of the subjects, but none in the oth...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.45 (18), p.1679-1687
Hauptverfasser:	Arafat, ElSayed S., Trimble, Joann W., Andersen, Richard N., Dass, Chhabil, Desiderio, Dominic M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - blood Analysis of complex biological substances Analytical, structural and metabolic biochemistry Animal Biological and medical sciences Fatty Acids - blood Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Humans
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Beschreibung
Zusammenfassung:	A family of five long-chain fatty acid carboxamides has been identified and semi-quantified in human plasma by GC-MS. One saturated and four unsaturated amides were found. Luteal phase plasma from 16 women was studied, and all five of the amides were found in ten of the subjects, but none in the other six. The structure of these endogenous amides was established by comparing their GC and MS characteristics with those of the synthetic amides prepared by ammonolysis of corresponding long-chain fatty acyl chlorides.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(89)90278-6