Physical and Structural Comparison of Oxyphenbutazone Monohydrate and Anhydrate

Two crystal forms of Oxyphenbutazone (a monohydrate and an anhydrate) were prepared by recrystallization. The forms were characterized by means of differential scanning calorimetry, thermogravimetry, infrared spectrophotometry, X-ray powder diffraction patterns, thermomicroscopy, scanning electron m...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1989-09, Vol.78 (9), p.758-763
Hauptverfasser:	Stoltz, M., Caira, M.R., Lotter, A.P., Van Der Watt, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calorimetry, Differential Scanning Chemical Phenomena Chemistry, Physical Medical sciences Microscopy, Electron, Scanning Models, Chemical Molecular Conformation Oxyphenbutazone - analogs & derivatives Oxyphenbutazone - analysis Pharmacology. Drug treatments Solubility Spectrophotometry, Infrared X-Ray Diffraction
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Beschreibung
Zusammenfassung:	Two crystal forms of Oxyphenbutazone (a monohydrate and an anhydrate) were prepared by recrystallization. The forms were characterized by means of differential scanning calorimetry, thermogravimetry, infrared spectrophotometry, X-ray powder diffraction patterns, thermomicroscopy, scanning electron microscopy, as well as powder and intrinsic dissolution rates. The crystal structure of the anhydrate has been elucidated and compared with that of the monohydrate.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600780912