The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with "low" or "high" cholesterol levels

The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with "low" or "high" cholesterol levels

A human volunteer study was conducted to test the effect of vitamin C supplementation on biomarkers of oxygen radical‐mediated damage in individuals with a range of serum cholesterol levels. A group of 48 non‐smokers, 24 men and 24 women, was selected from a panel of over 100 volunteers to give as w...

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Veröffentlicht in:Environmental and molecular mutagenesis 1997, Vol.30 (2), p.161-174
Hauptverfasser: Anderson, D., Phillips, B.J., Yu, Tian-Wei, Edwards, A.J., Ayesh, R., Butterworth, K.R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Antioxidants - metabolism
Ascorbic Acid - blood
Ascorbic Acid - therapeutic use
Biological and medical sciences
Bleomycin - pharmacology
Chemical mutagenesis
Cholesterol - blood
Chromosome Aberrations
comet assay
DNA Damage
Dose-Response Relationship, Drug
Female
Free Radicals
Genetic Techniques
human monitoring
Humans
Lipid Peroxidation
lymphocytes
Lymphocytes - drug effects
Male
Medical sciences
Middle Aged
Oxygen - metabolism
Proto-Oncogene Proteins p21(ras) - blood
Proto-Oncogene Proteins p21(ras) - drug effects
ras
Toxicology
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Zusammenfassung:A human volunteer study was conducted to test the effect of vitamin C supplementation on biomarkers of oxygen radical‐mediated damage in individuals with a range of serum cholesterol levels. A group of 48 non‐smokers, 24 men and 24 women, was selected from a panel of over 100 volunteers to give as wide a range of serum cholesterol levels as possible. None of the volunteers was taking medication to control cholesterol levels and they maintained their normal dietary habits so as not to compromise their cholesterol status. Volunteers were allocated to three groups of 16, each consisting of four males with low cholesterol levels (
ISSN:0893-6692
1098-2280
DOI:10.1002/(SICI)1098-2280(1997)30:2<161::AID-EM9>3.0.CO;2-Q