Blepharospasm associated with olivopontocerebellar atrophy

We report two cases of cranial dystonia (blepharospasm) associated with olivopontocerebellar atrophy (OPCA). The pathophysiology of blepharospasm appears to involve an increased excitability of the interneurons of the blink and corneal reflexes. It is hypothesized that blepharospasm associated with...

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Veröffentlicht in:	Journal of clinical neuro-ophthalmology 1989-12, Vol.9 (4), p.281-284
Hauptverfasser:	JANATI, A, METZER, W. S, ARCHER, R. L, NICKOLS, J, RAVAL, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blepharospasm - etiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Eyelid Diseases - etiology Female Humans Male Medical sciences Middle Aged Neurology Spinocerebellar Degenerations - complications Spinocerebellar Degenerations - diagnostic imaging Tomography, X-Ray Computed
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Zusammenfassung:	We report two cases of cranial dystonia (blepharospasm) associated with olivopontocerebellar atrophy (OPCA). The pathophysiology of blepharospasm appears to involve an increased excitability of the interneurons of the blink and corneal reflexes. It is hypothesized that blepharospasm associated with OPCA might be due to rostral brainstem lesions disrupting central dopaminergic and cholinergic pathways, resulting in disinhibition of brainstem reflexes or denervation supersensitivity of the facial nuclear complex.
ISSN:	0272-846X