HLA-C locus antigens seen by one-dimensional isoelectric focusing: Definition of the so far known HLA-C specificities and of two subtypes

A panel of homozygous typing cells was employed for biochemical definition of all known HLA-C locus antigens from Cw1 through Cw11. Each HLA-C antigen yielded, after precipitation with one of the monoclonal antibodies W6/32, 4E, or HC10, a specific banding pattern on one-dimensional isoelectric focu...

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Veröffentlicht in:	Human immunology 1989-12, Vol.26 (4), p.227-236
Hauptverfasser:	Hajek-Rosenmayr, Agathe, Jungl, Lisi, Stammler, Maria, Kirnbauer, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antigens Biological and medical sciences Epitopes - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility antigens (hla, h-2 and other systems) HLA-C Antigens - analysis HLA-C Antigens - genetics HLA-C Antigens - immunology Humans Isoelectric Focusing Molecular immunology
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Zusammenfassung:	A panel of homozygous typing cells was employed for biochemical definition of all known HLA-C locus antigens from Cw1 through Cw11. Each HLA-C antigen yielded, after precipitation with one of the monoclonal antibodies W6/32, 4E, or HC10, a specific banding pattern on one-dimensional isoelectric focusing gels. In addition, two biochemical subtypes of Cw1 and Cw7 could be identified. These biochemical HLA-C “splits” were characterized not only by different isoelectric points but also by strong linkage disequilibriums with certain HLA-B antigens.
ISSN:	0198-8859 1879-1166
DOI:	10.1016/0198-8859(89)90001-3