A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS
The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, iso...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1989-10, Vol.63 (4), p.489-491 |
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| container_end_page | 491 |
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| container_issue | 4 |
| container_start_page | 489 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 63 |
| creator | MCKENZIE, J. DOUGLAS CALOW, PETER NIMMO, WALTER S. |
| description | The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency. |
| doi_str_mv | 10.1093/bja/63.4.489 |
| format | Article |
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DOUGLAS</creatorcontrib><creatorcontrib>CALOW, PETER</creatorcontrib><creatorcontrib>NIMMO, WALTER S.</creatorcontrib><title>A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.</description><subject>Anesthesia, Inhalation</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Daphnia - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enflurane - pharmacology</subject><subject>Halothane - pharmacology</subject><subject>Isoflurane - pharmacology</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Movement - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1989-10, Vol.63 (4), p.489-491 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Anesthesia, Inhalation Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Daphnia - drug effects Dose-Response Relationship, Drug Enflurane - pharmacology Halothane - pharmacology Isoflurane - pharmacology Light Medical sciences Models, Biological Movement - drug effects Neuropharmacology Pharmacology. Drug treatments |
| title | A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS |
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