A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS

The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, iso...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1989-10, Vol.63 (4), p.489-491
Hauptverfasser:	MCKENZIE, J. DOUGLAS, CALOW, PETER, NIMMO, WALTER S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, Inhalation Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Daphnia - drug effects Dose-Response Relationship, Drug Enflurane - pharmacology Halothane - pharmacology Isoflurane - pharmacology Light Medical sciences Models, Biological Movement - drug effects Neuropharmacology Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/63.4.489