Alterations in Collagen Cross-Linking Impair Myocardial Contractility in the Mouse Heart

A number of genetic disorders in humans are associated with defects in the synthesis and metabolism of collagen, which are accompanied by multiple cardiovascular disease processes. To determine whether genetically determined cross-linking abnormalities of collagen may alter cardiac function, left ve...

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Veröffentlicht in:	Circulation research 1989-12, Vol.65 (6), p.1657-1664
Hauptverfasser:	Capasso, Joseph M, Robinson, Thomas F, Anversa, Piero
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight Calcium - physiology Collagen - physiology Collagen - ultrastructure Fundamental and applied biological sciences. Psychology Heart Heart - anatomy & histology Mice Mice, Mutant Strains Myocardial Contraction Organ Size Papillary Muscles - anatomy & histology Protein Binding Vertebrates: cardiovascular system
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Zusammenfassung:	A number of genetic disorders in humans are associated with defects in the synthesis and metabolism of collagen, which are accompanied by multiple cardiovascular disease processes. To determine whether genetically determined cross-linking abnormalities of collagen may alter cardiac function, left ventricular papillary muscles of mice with a genetic defect in the cross-linking of collagen (Mo) were studied in vitro. With respect to controls, increases in time to peak tension, from 102 ± 1.4 to 125 ± 5.4 msec (p
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.65.6.1657