Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction

The activities of superoxide dismutase ( Cu Zn ) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and th...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-10, Vol.164 (2), p.620-625
Hauptverfasser:	Semsei, Imre, Rao, Govinda, Richardson, Arlan
Format:	Artikel
Sprache:	eng
Schlagworte:	age Aging Animals Biological and medical sciences catalase Catalase - genetics Catalase - metabolism Cell Nucleus - metabolism diet Diet, Reducing Enzymes. Coenzymes. Vitamins. Pigments food restriction Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic liver Liver - enzymology Liver - growth & development Male Metabolisms and neurohumoral controls Rats Rats, Inbred F344 Reference Values RNA RNA, Messenger - analysis RNA, Messenger - genetics superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transcription, Genetic Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	The activities of superoxide dismutase ( Cu Zn ) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and the nuclear transcription of the superoxide dismutase and catalase genes. Life-long dietary restriction was shown to increase the expression (i.e. activities, mRNA levels, and nuclear transcription) of superoxide dismutase and catalase in liver tissue from 18-month-old rats.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(89)91505-2