A mitogen for Schwann cells is derived from myelin basic protein

Evidence is presented that a mitogen can be produced from myelin basic protein (MBP) which may be related to the Schwann cell proliferation characteristic of Wallerian degeneration. Myelin derived from the shiverer mutant which is devoid of MBP is also devoid of mitogenic activity. Absorption of the...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-10, Vol.164 (2), p.883-888
Hauptverfasser:	Baichwal, R.R., DeVries, G.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Cell cycle, cell proliferation Cell Division Cell physiology Cells, Cultured Fundamental and applied biological sciences. Psychology Liposomes Mice Mice, Mutant Strains Mitogens Molecular and cellular biology Myelin Basic Protein - isolation & purification Myelin Basic Protein - physiology Schwann Cells - cytology Sciatic Nerve - cytology
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Beschreibung
Zusammenfassung:	Evidence is presented that a mitogen can be produced from myelin basic protein (MBP) which may be related to the Schwann cell proliferation characteristic of Wallerian degeneration. Myelin derived from the shiverer mutant which is devoid of MBP is also devoid of mitogenic activity. Absorption of the mitogen with a polyclonal antisera to MBP abolishes the mitogenic effect. In addition, only liposomes containing MBP are mitogenic to cultured Schwann cells; liposomes containing other myelin-specific proteins do not stimulate Schwann cell division. These results directly demonstrate the MBP origin of a mitogen for Schwann cells.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(89)91541-6