Sorting and trafficking of ion transport proteins in polarized epithelial cells

Sorting and trafficking of ion transport proteins in polarized epithelial cells

Transport proteins are targeted to specific plasmalemmal domains in polarized epithelial cells. The molecular signals that govern these sorting events are just beginning to be elucidated. In many cases, the cell surface delivery of transport proteins is subjected to tight regulation. Several differe...

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Veröffentlicht in:Current opinion in nephrology and hypertension 1997-09, Vol.6 (5), p.455-459
Hauptverfasser: Muth, Theodore R, Dunbar, Lisa A, Cortois-Coutry, Nathalie, Roush, Denise L, Caplan, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Polarity
Epithelial Cells - cytology
Epithelial Cells - metabolism
Humans
Ion Transport
Proteins - metabolism
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Beschreibung
Zusammenfassung:Transport proteins are targeted to specific plasmalemmal domains in polarized epithelial cells. The molecular signals that govern these sorting events are just beginning to be elucidated. In many cases, the cell surface delivery of transport proteins is subjected to tight regulation. Several different mechanisms appear to participate in these trafficking processes.
ISSN:1062-4821
1473-6543
DOI:10.1097/00041552-199709000-00008