Nerve growth factor depletion by autoimmunization produces thermal hypoalgesia in adult rats

Nerve growth factor depletion by autoimmunization produces thermal hypoalgesia in adult rats

Nerve growth factor (NGF) plays a role in mechanisms of inflammation and hyperalgesia in adult animals. We sought to determine if NGF depletion produced by autoimmunization of adult rats altered their thermal sensitivity to an acute noxious thermal stimulus. Anti-NGF IgG was not detected in the cere...

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Veröffentlicht in:Brain research 1997-08, Vol.765 (2), p.327-330
Hauptverfasser: Chudler, Eric H, Anderson, Leigh C, Byers, Margaret R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Autoimmunization
Cerebrospinal fluid
Hot plate test
Immunization
Male
Models, Neurological
Nerve growth factor
Nerve Growth Factors - pharmacology
Nociception
Pain Measurement
Rats
Rats, Sprague-Dawley
Sensory Thresholds - drug effects
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Zusammenfassung:Nerve growth factor (NGF) plays a role in mechanisms of inflammation and hyperalgesia in adult animals. We sought to determine if NGF depletion produced by autoimmunization of adult rats altered their thermal sensitivity to an acute noxious thermal stimulus. Anti-NGF IgG was not detected in the cerebrospinal fluid of any tested samples. Only those rats with the highest anti-NGF serum titers showed significant ( P
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00681-1