The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide a in systemic meningococcal disease

We have evaluated the quantitative relationship between lipopolysaccharide (LPS, endotoxin), fibrinopeptide A (FPA), antithrombin (AT), protein C (PC) and extrinsic pathway inhibitor (EPI) in plasma from 39 consecutively admitted patients with systemic meningococcal disease (SMD). The most severely...

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Veröffentlicht in:	Thrombosis research 1989-08, Vol.55 (4), p.459-470
Hauptverfasser:	Brandtzaeg, Petter, Sandset, Per Morten, Joø, Gun Britt, Øvstebø, Reidun, Abildgaard, Ulrich, Kierulf, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin III - analysis Biological and medical sciences Blood coagulation. Blood cells Coagulation factors Coagulation inhibitors disseminated intravascular coagulation Disseminated Intravascular Coagulation - blood Disseminated Intravascular Coagulation - etiology endotoxin Endotoxins - blood Factor VII - analysis Factor VII - antagonists & inhibitors Fibrinogen - analysis Fibrinopeptide A - analysis formula omitted Fundamental and applied biological sciences. Psychology Humans Lipopolysaccharides - blood Lipoproteins - analysis Meningitis, Meningococcal - blood Meningococcal Infections - blood Meningococcal Infections - complications Molecular and cellular biology Multiple Organ Failure - blood Multiple Organ Failure - etiology Neisseria meningitidis plasmapheresis Protein C - analysis Sepsis - blood Sepsis - complications Thromboplastin - analysis Thromboplastin - antagonists & inhibitors
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Zusammenfassung:	We have evaluated the quantitative relationship between lipopolysaccharide (LPS, endotoxin), fibrinopeptide A (FPA), antithrombin (AT), protein C (PC) and extrinsic pathway inhibitor (EPI) in plasma from 39 consecutively admitted patients with systemic meningococcal disease (SMD). The most severely ill patients with fulminant meningococcal septicemia (n=13, 6 dead) had significantly (p
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(89)90054-6